Mechanism of the local vascular actions or 1, 1-dimethyl-4-phenylpiperazinium (DMPP), a potent ganglionic stimulant

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The anti-inflammatory effects of 1,1 dimethyl-4-phenylpiperazinium (DMPP) compared to dexamethasone in a guinea pig model of ovalbumin induced asthma.

BACKGROUND AND AIM Inflammatory cells involved in the pathophysiology of asthma express nicotinic receptor. Therefore 1,1 dimethyl(-4-)phenylpiperazinium (DMPP) in two doses were compared to dexamethasone in asthmatic guinea pigs. MATERIALS AND METHODS Six groups were included; Normal control and five asthmatic (OVA-sensitized and challenged) groups; which were treated for 10 days as follows:...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 1959

ISSN: 0022-3751

DOI: 10.1113/jphysiol.1959.sp006217